【封面论文】太原理工大学马梓钧、李梦、杨晓宁、桑胜波等:一种具有生物相容性和机械强度的新型多组分协同生物墨水用于促进软骨再生
- 2026-03-07 04:14:52
Cover story
Articular cartilage defects resulting from trauma, surgical resection, or degenerative conditions pose a significant therapeutic challenge in orthopaedics due to their low intrinsic healing capacity. Hydrogels, owing to their porous network structure resembling the extracellular matrix (ECM), have become essential scaffold materials in cartilage tissue engineering. Among them, GelMA hydrogels are widely used in bioink development due to their excellent biocompatibility, biodegradability, and tunable photocrosslinking properties. However, the high biocompatibility of pure GelMA often comes at the cost of insufficient mechanical strength, limiting its suitability for cartilage regeneration.To address this challenge, this study introduces a GS/PEO composite hydrogel system that integrates GelMA with mechanically robust SF and a pore-forming polymer. This combination yields bioinks with excellent printability, structural fidelity, and a highly porous microstructure, while providing mechanical properties well aligned with the requirements of cartilage repair. After printing, the composite hydrogel supported long-term chondrocyte viability and sustained secretion of collagen II and aggrecan.This work presents a versatile strategy for balancing biocompatibility and mechanical strength in bioinks, offering a promising platform for next-generation cartilage tissue engineering. The cover image illustrates the pore formation process and highlights the progression of cartilage repair.
(Image drawn by Zijun MA, Taiyuan University of Technology, Taiyuan, China)
中文摘要
水凝胶因其类似于细胞外基质的多孔网络结构，已成为软骨组织工程领域必不可少的支架材料。其中，甲基丙烯酸明胶（GelMA）水凝胶因其优异的生物相容性、生物降解性和可调的光交联性能而广泛应用于生物墨水开发。然而，纯GelMA的高生物相容性往往以机械强度为代价，限制了其在软骨再生中的适用性。为了克服这种制约关系，本研究开发了基于GelMA、丝素蛋白（SF）和聚环氧乙烷（PEO）的复合生物墨水，用于制备多孔水凝胶支架，然后从形貌、孔隙率、亲水性、机械强度、流变行为、可印刷性和细胞相容性等方面对其进行了系统表征。在这种设计中，PEO作为致孔剂产生高度多孔的结构（孔隙率高达88%），而SF补偿了PEO造成的机械损失，使支架能够保持高达29.10 kPa的压缩强度。在测试的配方中，10% GelMA/1% SF/1.5% PEO（1%=0.01 g/mL）生物墨水表现出优异的打印性能、机械性能和细胞相容性，并且在打印后支持软骨细胞对II型胶原和聚集蛋白聚糖的牢固沉积。这项工作为平衡生物墨水的生物相容性和机械性能提供了一种多功能策略，为下一代软骨组织工程支架提供了一个有前景的平台。
作者：
本文引用格式：
Zijun MA, Wendan JIA, Xiaoyuan WANG, Rong CHENG, Lu HAN, Meng LI, Xiaoning YANG, Shengbo SANG. Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration. Journal of Zhejiang University-SCIENCE B, 26(12):1156-1171.
https://jzus.zju.edu.cn/opentxt.php?doi=10.1631/jzus.B2500343
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