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太原理工大学综述:下一代关节器官芯片

  • 2026-04-19 23:52:36
太原理工大学综述:下一代关节器官芯片
骨关节炎是全球导致残疾的主要原因之一，目前尚无药物疗法能够逆转其病程。这一治疗手段的缺失主要归因于传统关节生理学和病理学体外模型的不足，这严重阻碍了疾病机制研究和药物开发的进展。器官芯片（OoC），也被称为微生理系统，整合了微流控技术与组织工程技术，用于构建小型化的体外组织培养平台，可重现人体器官的关键功能。
作为一种新兴的关节体外模型，关节器官芯片（JoC）技术能够低成本、高效地模拟关节的生理和病理活动，成为当前研究的热点。为平衡实验复杂性与生理相关性，JoC至少应整合软骨、软骨下骨和滑膜，并复现与关节稳态密切相关的机械刺激。
据麦姆斯咨询介绍，太原理工大学联合香港中文大学研究团队在国际顶级期刊Nano-Micro Letters发表了题为“Next-Generation Joint-on-a-Chip: Toward Precision Mechanical Control in Multi-Tissue Systems”的最新研究成果。该综述聚焦了具有生理相关性的JoC系统设计，探讨合理的工程设计如何更好地复现以多组织串扰和机械刺激为特征的复杂关节微环境。
图1 JoC技术中关节微环境模型
图2 JoC模型整合各类机械刺激的示意图
论文聚焦关节体外模型的创新构建，提出了新一代JoC概念，能够高效、低成本地模拟关节的生理与病理活动，特别是在多组织培养协同精确机械刺激方面取得了重要突破。
论文系统分析了软骨、软骨下骨及滑膜等关节关键组织的结构与功能，明确了JoC需复现的微环境特征，并展示了实现多组织共培养与特定力学刺激的无缝整合的JoC原型概念方案。该研究旨在为高性能体外关节模型的构建提供新方法，推动骨关节炎疾病机制研究和药物开发。
图3 包含多种关节组织的代表性JoC系统示意图
在此基础上，该研究梳理了现有的模拟多组织共培养和机械刺激的JoC类型，总结出与芯片集成相关的两个关键问题：机械刺激的精准控制和芯片设计的优化。为解决这些挑战，研究提出了梯度柱体和表面通透性相关解决方案，并进一步构建了理想化的JoC模型。
本论文的创新点在于首次系统提出了整合多组织共培养与精准力学调控的JoC设计框架，为模拟真实关节微环境提供了新思路。该技术有望突破传统模型的局限，推动骨关节炎等疾病的机制解析与药物筛选进程，为未来个性化医疗和再生医学研究奠定基础。
论文链接：
https://doi.org/10.1007/s40820-025-02031-5

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  1. CONNECT:[ UseTime:0.000452s ] mysql:host=127.0.0.1;port=3306;dbname=h460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000724s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.003059s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000344s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000639s ]
  6. SELECT * FROM `set` [ RunTime:0.000260s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000590s ]
  8. SELECT * FROM `article` WHERE `id` = 495499 LIMIT 1 [ RunTime:0.000767s ]
  9. UPDATE `article` SET `lasttime` = 1777085912 WHERE `id` = 495499 [ RunTime:0.001862s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000293s ]
  11. SELECT * FROM `article` WHERE `id` < 495499 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000504s ]
  12. SELECT * FROM `article` WHERE `id` > 495499 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000481s ]
  13. SELECT * FROM `article` WHERE `id` < 495499 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000920s ]
  14. SELECT * FROM `article` WHERE `id` < 495499 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.006069s ]
  15. SELECT * FROM `article` WHERE `id` < 495499 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.006548s ]
0.095298s